{"id":64612,"date":"2022-10-20T08:25:08","date_gmt":"2022-10-20T07:25:08","guid":{"rendered":"https:\/\/www.dentaly.org\/us\/?page_id=64612"},"modified":"2024-11-12T11:29:10","modified_gmt":"2024-11-12T10:29:10","slug":"stem-cells","status":"publish","type":"page","link":"https:\/\/www.dentaly.org\/us\/dental-services\/stem-cells\/","title":{"rendered":"Dental Stem Cells: Regenerative Dentistry and its Applications"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Let&#8217;s talk about <strong>dental stem cells<\/strong>. A few years ago &#8216;stem cells&#8217; was a buzzword, a hot-button topic that would send politically opposed radicals at each other&#8217;s throats.<\/p>    <p class=\"wp-block-paragraph\">But today, stem cell research is a rapidly progressing scientific field, with promising medical advances that are greatly improving lives globally.<\/p>    <p class=\"wp-block-paragraph\">Dental stem cells are currently still in the research and clinical trial phase but so far they have shown great potential to treat a wide range of ailments across the entire body \u2014 the brain, the musculoskeletal system, the GI tract, and of course, the teeth. <\/p>    <p class=\"wp-block-paragraph\">In this article, we&#8217;ll catch you up on the latest in the world of dental stem cells and answer these questions: <\/p>    <ul class=\"wp-block-list\"> <li>What are dental pulp stem cells?<\/li>    <li>How are they collected?<\/li>    <li>What are their current and future applications?<\/li> <\/ul>    <p class=\"wp-block-paragraph\">We also interview Dr. Ophir Klein, a Stemodontics team member, so you can hear it straight from a professional in the field. <\/p>    <p class=\"wp-block-paragraph\">If you&#8217;re interested in learning more about other specialized fields of dentistry, you can have a look at them in our <a rel=\"noreferrer noopener\" href=\"https:\/\/www.dentaly.org\/us\/dental-services\/\" data-type=\"page\" data-id=\"19461\" target=\"_blank\">dental services<\/a> guide. <\/p>    <h2 id=\"stem-cells-the-basics\" class=\"wp-block-heading\">Stem cells: the basics<\/h2>    <p class=\"wp-block-paragraph\">Stem cells are cells which generate all of the other cells in the body that have specialized functions. Stem cells divide to form these other cells which are called daughter cells. <\/p>    <p class=\"wp-block-paragraph\">Daughter cells can become more stem cells, or they can become specialized cells. If they become specialized cells, this is called differentiation. They may become blood cells, heart muscle cells, bone cells, or brain cells. <\/p>    <p class=\"wp-block-paragraph\">Stem cells are special because they are the only cells that have the ability to form other stem cells, or to create new specialized cells. <\/p>    <figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube\"><div style=\"display: contents;\" > \t\t\t<div data-mode=\"normal\" data-oembed=\"1\" data-provider=\"youtube\" id=\"arve-youtube-o0dnh6ka6sw\" class=\"arve\"> \t\t\t\t<div class=\"arve-inner\"> \t\t\t\t\t<div class=\"arve-embed arve-embed--has-aspect-ratio\"> \t\t\t\t\t\t<div class=\"arve-ar\" style=\"padding-top:56.250000%\"><\/div> \t\t\t<iframe allow=\"accelerometer &apos;none&apos;;autoplay &apos;none&apos;;bluetooth &apos;none&apos;;browsing-topics &apos;none&apos;;camera &apos;none&apos;;clipboard-read &apos;none&apos;;clipboard-write;display-capture &apos;none&apos;;encrypted-media &apos;none&apos;;gamepad &apos;none&apos;;geolocation &apos;none&apos;;gyroscope &apos;none&apos;;hid &apos;none&apos;;identity-credentials-get &apos;none&apos;;idle-detection &apos;none&apos;;keyboard-map &apos;none&apos;;local-fonts;magnetometer &apos;none&apos;;microphone &apos;none&apos;;midi &apos;none&apos;;otp-credentials &apos;none&apos;;payment &apos;none&apos;;picture-in-picture;publickey-credentials-create &apos;none&apos;;publickey-credentials-get &apos;none&apos;;screen-wake-lock &apos;none&apos;;serial &apos;none&apos;;summarizer &apos;none&apos;;sync-xhr;usb &apos;none&apos;;web-share;window-management &apos;none&apos;;xr-spatial-tracking &apos;none&apos;;\" allowfullscreen=\"\" class=\"arve-iframe fitvidsignore\" credentialless data-arve=\"arve-youtube-o0dnh6ka6sw\" data-lenis-prevent=\"\" data-src-no-ap=\"https:\/\/www.youtube-nocookie.com\/embed\/O0dnh6ka6sw?feature=oembed&amp;iv_load_policy=3&amp;modestbranding=1&amp;rel=0&amp;autohide=1&amp;playsinline=0&amp;autoplay=0\" frameborder=\"0\" height=\"0\" loading=\"lazy\" name=\"\" referrerpolicy=\"strict-origin-when-cross-origin\" sandbox=\"allow-scripts allow-same-origin allow-presentation allow-popups allow-popups-to-escape-sandbox\" scrolling=\"no\" src=\"https:\/\/www.youtube-nocookie.com\/embed\/O0dnh6ka6sw?feature=oembed&#038;iv_load_policy=3&#038;modestbranding=1&#038;rel=0&#038;autohide=1&#038;playsinline=0&#038;autoplay=0\" title=\"\" width=\"0\"><\/iframe> \t\t\t\t\t\t\t\t<\/div> \t\t\t\t\t\t\t\t\t<\/div> \t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div> \t\t\t <\/div><\/figure>    <h3 class=\"wp-block-heading\">Why are stem cells so important?<\/h3>    <p class=\"wp-block-paragraph\">Stem cells are critical in helping researchers: <\/p>    <ul class=\"wp-block-list\"> <li><strong>Understand disease:<\/strong> By observing how stem cells evolve into organ and tissue cells, researchers can see how diseases develop<\/li>    <li><strong>Advance regenerative medicine:<\/strong> Researchers hope to expand on the practice of using stem cell therapy to repair tissue damaged by disease or trauma<\/li>    <li><strong>Test new drugs: <\/strong>Cells with specialized functions can be used to test specific drugs<\/li> <\/ul>    <p class=\"wp-block-paragraph\">Stem cells have greatly contributed to regenerative medicine \u2014 that of replacing or regenerating damaged human cells for curative purposes. <\/p>    <p class=\"wp-embed-aspect-16-9 wp-has-aspect-ratio wp-block-paragraph\">     <div class=\"dentist-tip\">          <div class=\"dentist-tip__title\">             Ask an Expert: Do you think we will ever be able to regrow teeth from stem cells?        <\/div>          <div class=\"dentist-tip__content\">             <\/p>    <p class=\"wp-block-paragraph\">That is a great question and one that we debate a lot in the dental research community. On the one hand, there has been enormous progress in organ bioengineering over the past few years, so there is reason for optimism about growing an entire tooth. <\/p>    <p class=\"wp-block-paragraph\">However, teeth take a long time to mature, so there is an alternative school of thought that says the following: we are very good at making dental materials (to fix the hard part on the outside of the tooth), so rather than growing an entire tooth, let\u2019s focus on regrowing the living part \u2013 the cells on the inside \u2013 and then put an artificial cap on the outside. <\/p>    <p class=\"wp-block-paragraph\">I think the jury is still out as to which approach will work better in the long run.<\/p>    <p class=\"wp-embed-aspect-16-9 wp-has-aspect-ratio wp-block-paragraph\"><strong>Dr. Ophir Klein, MD, PhD<\/strong>, <strong>Stemodontics<\/strong><\/p>    <p class=\"wp-embed-aspect-16-9 wp-has-aspect-ratio wp-block-paragraph\">        <\/div>      <\/div>      <\/p>    <h2 id=\"dental-stem-cells\" class=\"wp-block-heading\">Dental stem cells<\/h2>    <p class=\"wp-block-paragraph\">The regeneration of dental pulp began to catch researchers&#8217; eyes thanks to the work of stomatologist G.L. Feldman in 1932. He was able to achieve pulp regeneration using fillings made from dentin. Then, in 2000, this work was improved on by <a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12147742\/\" target=\"_blank\">Stan Gronthos<\/a>, and the cells used to do so were referred to as dental pulp stem cells, now known as DPSCs. <\/p>   <div class=\"wp-block-image\"> <figure class=\"alignright size-large\"><img decoding=\"async\" width=\"300\" height=\"220\" src=\"https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2020\/12\/tooth-structure-image.svg\" alt=\"dental pulp stem cells\" class=\"wp-image-30882\" \/><figcaption class=\"wp-element-caption\">Dental stem cells come from the pulp<\/figcaption><\/figure> <\/div>   <h3 class=\"wp-block-heading\">Dental pulp stem cells <\/h3>    <p class=\"wp-block-paragraph\"><strong>DPSCs are mesenchymal stem cells<\/strong> (MSCs), meaning they are multipotent cells, found in bone marrow, which are important for creating skeletal tissues, like bone, cartilage, and fat. <\/p>    <p class=\"wp-block-paragraph\">This is useful because bone marrow has a limited amount of MSCs, and these decrease with age and disease, and they also have been shown to decrease when someone is overweight. This decrease in MSCs essentially leads to weaker bones. <\/p>    <p class=\"wp-block-paragraph\">DPSCs can differentiate (or become) dentin cells in vitro (or outside of their natural environment \u2014 in a lab for example) and inside of their natural environment they can become &#8220;dentin-pulp-like complex&#8221; according to <a rel=\"noreferrer noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC17626\/\" target=\"_blank\">this Stan Gronthos study<\/a>. <\/p>    <p class=\"wp-block-paragraph\">DPSCs are considered to be good candidates for the regeneration of dental tissue for four primary reasons: <\/p>    <ul class=\"wp-block-list\"> <li>They are easy to access during surgery and easy to keep alive after<\/li>    <li>They generate more dentin tissue faster than stem cells that don&#8217;t come from the teeth<\/li>    <li>They can be cryopreserved and combined in various tissue regeneration support structures<\/li>    <li>They have anti-inflammatory properties which are helpful in allotransplantation (transplanting tissue from the same species)<\/li> <\/ul>    <p class=\"wp-block-paragraph\"><\/p>    <h2 id=\"dental-pulp-stem-cell-banking-from-wisdom-teeth\" class=\"wp-block-heading\">Dental pulp stem cell banking from wisdom teeth<\/h2>    <p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.dentaly.org\/us\/wisdom-teeth\/\" data-type=\"page\" data-id=\"1809\" target=\"_blank\" rel=\"noreferrer noopener\">Wisdom tooth<\/a> extraction is an ideal time for retrieving DPSCs, because these cells are at their peak viability when patients are between the ages of 12 to 24 which is typically when wisdom teeth are removed. <\/p>    <h3 class=\"wp-block-heading\">How does dental stem cell banking work?<\/h3>    <p class=\"wp-block-paragraph\">If your <a rel=\"noreferrer noopener\" href=\"https:\/\/www.dentaly.org\/us\/dental-services\/oral-surgeon-near-me\/\" data-type=\"page\" data-id=\"21863\" target=\"_blank\">oral surgeon<\/a> is going to bank wisdom tooth stem cells, the good news is, the wisdom tooth extraction process is no different from the patient&#8217;s point of view. <\/p>    <p class=\"wp-block-paragraph\">The only variance from the regular procedure is that once the wisdom teeth are extracted, they are put into a special solution that keeps the stem cells viable when normally, they are discarded into a medical waste container. <\/p>    <p class=\"wp-block-paragraph\">The next step is to remove the stem cells from the tooth and grow them in vitro, in a Petri dish, and freeze them. They can be preserved like this for as long as necessary, and used in clinical trials and studies. <\/p>    <h3 class=\"wp-block-heading\">DPSC from wisdom teeth and the future<\/h3>    <p class=\"wp-block-paragraph\">We asked Dr. Ophir Klein, MD, PhD, a Stemodontics board member, about the specifics of the process of banking stem cells from wisdom teeth: <\/p>    <p class=\"wp-block-paragraph\"><strong>What are the benefits of collecting and storing stem cells from wisdom teeth?<\/strong><\/p>    <p class=\"wp-block-paragraph\"> <em>These cells have the potential to become many different types of cells in the adult body, and by collecting them from young patients whose stem cells are healthy and have not suffered age-related damage, we can provide an \u201cinsurance policy\u201d for the life of the patient. <\/em><\/p>    <p class=\"wp-block-paragraph\"><em>In addition, there is growing evidence that beyond their regenerative potential, stem cells can be used to treat various diseases by modulating inflammation and through other mechanisms<\/em>.<\/p>   <div class=\"wp-block-image\"> <figure class=\"alignright size-medium\"><img decoding=\"async\" width=\"300\" height=\"200\" src=\"https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2016\/04\/tooth-removal-300x200.jpg\" alt=\"dental stem cell\" class=\"wp-image-3778\" srcset=\"https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2016\/04\/tooth-removal-300x200.jpg 300w, https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2016\/04\/tooth-removal-65x43.jpg 65w, https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2016\/04\/tooth-removal-220x147.jpg 220w, https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2016\/04\/tooth-removal-150x100.jpg 150w, https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2016\/04\/tooth-removal-358x238.jpg 358w, https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2016\/04\/tooth-removal.jpg 500w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-element-caption\">When you get your wisdom tooth out, you can also bank your stme cells<\/figcaption><\/figure> <\/div>   <p class=\"wp-block-paragraph\"><strong>Are the stem cells you collect now already being used to benefit your patients? If not, when do you see this happening?<\/strong><\/p>    <p class=\"wp-block-paragraph\"><em>We are at the beginning of an exciting journey in the therapeutic use of adult stem cells. At this point, there are many clinical trials going on using DPSCs, and we anticipate that these will be deployed clinically in the coming years.&nbsp;<\/em><\/p>    <p class=\"wp-block-paragraph\"><strong>What are some practical applications of dental pulp stem cells?<\/strong><\/p>    <p class=\"wp-block-paragraph\"><em>There are hundreds of studies documenting potential practical applications of DPSCs. These cut across multiple organs, including the brain, gastrointestinal tract, musculoskeletal system, and other parts of the body.<\/em><\/p>    <p class=\"wp-block-paragraph\"><strong>Can stem cells be used to repair teeth?<\/strong><\/p>    <p class=\"wp-block-paragraph\"><em>Yes \u2013 there are exciting preliminary reports of the use of DPSCs in the repair of injured teeth, including revitalizing the pulp, which is particularly important because death of the pulp requires painful procedures like root canals. If we can routinely revitalize the pulp using stem cells, that would be an enormous benefit to patients.<\/em><\/p>    <h2 id=\"conclusion\" class=\"wp-block-heading\">Conclusion<\/h2>   <div class=\"wp-block-image\"> <figure class=\"alignright size-medium\"><img decoding=\"async\" width=\"300\" height=\"166\" src=\"https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2022\/10\/dental-stem-cells-1-300x166.jpg\" alt=\"are dental stem cells available\" class=\"wp-image-64680\" srcset=\"https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2022\/10\/dental-stem-cells-1-300x166.jpg 300w, https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2022\/10\/dental-stem-cells-1-1024x567.jpg 1024w, https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2022\/10\/dental-stem-cells-1-768x425.jpg 768w, https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2022\/10\/dental-stem-cells-1-1536x850.jpg 1536w, https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2022\/10\/dental-stem-cells-1.jpg 2002w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-element-caption\">Dental stem cells have the potential to aid in treating many ailments<\/figcaption><\/figure> <\/div>   <p class=\"wp-block-paragraph\">Dental stem cell research is advancing at a rapid rate and showing great potential to aid in the treatment of ailments not just of the mouth, but across the entire body. <\/p>    <p class=\"wp-block-paragraph\">Dental pulp stem cells can be banked during wisdom tooth extraction, without any impact on the patient, frozen and stored, and used in research and clinical trials until they are approved for actual use in patients. <\/p>    <p class=\"wp-block-paragraph\">From revitalizing pulp to regenerating the brain, or regrowing new teeth, the possibilities for the applications of dental pulp stem cells are practically endless, so be sure to follow along with the rapid advancements in this exciting field in the coming years. <\/p>    <p class=\"wp-block-paragraph\">If you&#8217;re interested in learning more about tooth regeneration, you can read our separate article about <a href=\"https:\/\/www.dentaly.org\/us\/teeth-implants-cost\/stem-cell-dental-implants\/\" data-type=\"page\" data-id=\"66072\" target=\"_blank\" rel=\"noreferrer noopener\">stem cell dental implants<\/a>. <\/p>    <h2 id=\"faqs\" class=\"wp-block-heading\">FAQs<\/h2>    <h3 class=\"wp-block-heading\">Can stem cells regrow teeth?<\/h3>    <p class=\"wp-block-paragraph\">Stem cells can&#8217;t regrow teeth just quite yet, and the process to do so takes time, so scientists are considering an alternative \u2014 regrowing the inside of the tooth, and reconstructing the outside.<\/p>    <h3 class=\"wp-block-heading\">What are dental stem cells used for?<\/h3>    <p class=\"wp-block-paragraph\">Dental stem cells are being researched for their great potential to regenerate new tissue including dentin, gum tissue, tooth pulp, bone tissue, and even whole teeth. <\/p>    <h3 class=\"wp-block-heading\">Are dental stem cells available?<\/h3>    <p class=\"wp-block-paragraph\">Dental stem cells are not currently available for use in medical procedures as they don&#8217;t have FDA approval and more research is needed. But they have great potential and research is advancing. <\/p> <div class=\"socials_share\"><ul class=\"share-buttons\">     <li class=\"share_item share_item-facebook\">         <a class=\"share_link share-facebook\"            href=\"https:\/\/www.facebook.com\/sharer?u=https:\/\/www.dentaly.org\/us\/dental-services\/stem-cells\/&amp;t=Dental+Stem+Cells%3A+Regenerative+Dentistry+and+its+Applications\"            target=\"_blank\"            rel=\"noopener noreferrer nofollow\"            title=\"Share to Facebook\"            onclick=\"window.open(this.href,'facebook-share','width=580,height=296');return false;\">             <svg width=\"30\" height=\"31\" viewbox=\"0 0 30 31\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">                 <rect y=\"0.194702\" width=\"30\" height=\"30\" rx=\"2\" fill=\"#4267B2\"\/>                 <path d=\"M13.0479 23.4202C12.9455 23.4202 12.6409 23.4197 12.432 23.2037C12.2626 23.029 12.243 22.8015 12.243 22.6458C12.2523 20.6126 12.2508 18.5806 12.2495 16.5483L12.2489 15.6189V15.6158C12.2427 15.6158 12.2368 15.6158 12.2308 15.6158L11.8509 15.6152L10.6452 15.6158V12.0132L11.7258 12.0147C11.8307 12.0147 11.9347 12.0144 12.039 12.0135L12.134 12.0132L12.248 12.0138C12.248 11.9597 12.2486 11.8992 12.2498 11.8304L12.2511 11.7639C12.2614 11.2385 12.2723 10.6949 12.3034 10.1583C12.4021 8.46772 13.7779 7.15315 15.5749 7.03252C16.2603 6.98761 16.9544 6.98329 17.6252 6.97926C17.95 6.97725 18.2748 6.97524 18.5995 6.9689H18.6017C18.8303 6.9689 18.9931 7.02619 19.114 7.13876C19.3021 7.3141 19.3002 7.55132 19.2996 7.62963C19.2933 8.25035 19.2877 9.06742 19.3011 9.88679C19.3052 10.0952 19.2423 10.2622 19.1146 10.3826C18.9231 10.5628 18.6631 10.5628 18.5777 10.5628C18.0041 10.5556 17.5255 10.5582 17.0105 10.5625C16.786 10.5639 16.7489 10.5982 16.7449 10.8066C16.7411 10.9984 16.7417 11.1895 16.7427 11.3807C16.7433 11.5923 16.7439 11.8042 16.7393 12.0158C17.1948 12.0086 17.642 12.0109 18.092 12.0135L19.2731 12.0153L19.3235 12.359C19.3267 12.3815 19.3307 12.401 19.3344 12.4189C19.346 12.4768 19.3603 12.5487 19.3528 12.6351C19.3248 12.923 19.2961 13.2063 19.2675 13.4896C19.2146 14.0124 19.1616 14.535 19.1155 15.0578C19.1009 15.2254 19.0056 15.6161 18.4401 15.6161L18.2498 15.6155L17.3863 15.6184C17.1693 15.6184 16.9519 15.6166 16.7355 15.6114C16.7433 17.7575 16.7417 19.9041 16.7399 22.0527L16.7396 22.5683C16.7396 23.2311 16.5465 23.413 15.8415 23.4148L14.2677 23.4113C13.8741 23.4113 13.4805 23.4133 13.0869 23.4202L13.0489 23.4205L13.0479 23.4202Z\"                       fill=\"white\"\/>             <\/svg>         <\/a>     <\/li>     <li class=\"share_item share_item-twitter\">         <a class=\"share_link share-twitter\"            href=\"https:\/\/twitter.com\/intent\/tweet?text=Dental+Stem+Cells%3A+Regenerative+Dentistry+and+its+Applications&amp;url=https:\/\/www.dentaly.org\/us\/dental-services\/stem-cells\/\"            rel=\"noopener noreferrer nofollow\"            arget=\"_blank\"            title=\"Share to Twitter\"            onclick=\"window.open(this.href,'twitter-share','width=580,height=296');return false;\" target=\"_blank\">             <svg width=\"31\" height=\"31\" viewbox=\"0 0 31 31\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">                 <rect x=\"0.194702\" y=\"0.194702\" width=\"30\" height=\"30\" rx=\"2\" fill=\"#22ABE9\"\/>                 <path d=\"M7.33932 22.3271C8.84491 23.0526 10.4272 23.4205 12.0504 23.4205H12.0514C17.2023 23.4202 22.644 19.4411 23.0785 11.8383C23.1172 11.1913 23.2438 10.5148 23.9054 9.94447C24.0772 9.79603 24.2332 9.62309 24.3882 9.43595L22.6351 9.90221L24.0389 7.80671C23.76 7.91857 23.481 8.03042 23.2038 8.14335C22.6579 8.36458 22.1906 8.27722 21.6767 7.85393C20.4451 6.83726 19.1047 6.69486 17.7456 7.43527C16.3857 8.17496 15.7162 9.40754 15.7562 11.0989C15.7631 11.4128 15.7406 11.7687 15.5126 12.0208C15.3094 12.2449 15.0364 12.318 14.5834 12.2502C11.7004 11.817 9.25204 10.4576 7.30694 8.20904C7.28811 8.18774 7.27059 8.16573 7.25373 8.143C6.65989 9.29924 6.98837 10.7154 8.29502 12.8276L8.87002 13.7566L7.6136 13.4526C7.3955 13.4 7.1893 13.3503 6.9778 13.2988C7.2273 14.8336 8.05477 15.8528 9.60133 16.5598L11.0914 17.2416L8.5888 17.5136C8.87102 18.3325 9.50253 18.84 11.5742 19.8037L12.2212 20.1049L11.6631 20.5683C10.2864 21.7121 8.76725 22.1478 7.33932 22.3271Z\"                       fill=\"white\"\/>             <\/svg>         <\/a>     <\/li>     <li class=\"share_item share_item-whatsapp-web\">         <a class=\"share_link share-whatsapp-web\" href=\"https:\/\/web.whatsapp.com\/send?text=https:\/\/www.dentaly.org\/us\/dental-services\/stem-cells\/\"            onclick=\"window.open(this.href,'whatsapp-share','width=780,height=400');return false;\"            title=\"Share to WhatsApp\" target=\"_blank\" rel=\"nofollow\">             <svg width=\"31\" height=\"31\" viewbox=\"0 0 31 31\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">                 <rect width=\"31\" height=\"31\" rx=\"2\" fill=\"url(#paint0_linear)\"\/>                 <path d=\"M22.4549 7.08199C20.4262 5.0533 17.7213 3.93445 14.8443 3.93445C8.91803 3.93445 4.08607 8.75412 4.08607 14.6926C4.08607 16.5861 4.57787 18.4426 5.52459 20.0656L4 25.6353L9.70492 24.1353C11.2787 24.9959 13.0492 25.4385 14.8443 25.4385C20.7705 25.4385 25.6025 20.6189 25.6025 14.6803C25.6025 11.8156 24.4959 9.12297 22.4549 7.08199ZM14.8566 23.6312C13.2459 23.6312 11.6721 23.2008 10.3074 22.3894L9.97541 22.1926L6.59426 23.0779L7.4918 19.7828L7.28279 19.4385C6.38525 18.0123 5.91803 16.3648 5.91803 14.6803C5.91803 9.75002 9.92623 5.74182 14.8566 5.74182C17.2418 5.74182 19.4918 6.67625 21.1762 8.36068C22.8607 10.0451 23.7951 12.2951 23.7951 14.6803C23.7828 19.623 19.7746 23.6312 14.8566 23.6312ZM19.75 16.9426C19.4795 16.8074 18.1639 16.1558 17.918 16.0697C17.6721 15.9836 17.4877 15.9345 17.3156 16.2049C17.1311 16.4754 16.6271 17.0779 16.4672 17.2623C16.3074 17.4467 16.1598 17.459 15.8893 17.3238C15.6189 17.1885 14.7582 16.9058 13.7254 15.9959C12.9262 15.2828 12.3852 14.3976 12.2254 14.1394C12.0656 13.8689 12.2131 13.7213 12.3484 13.5861C12.4713 13.4631 12.6189 13.2664 12.7541 13.1189C12.8893 12.959 12.9385 12.8484 13.0246 12.6763C13.1107 12.4918 13.0738 12.3443 13 12.209C12.9385 12.0738 12.3975 10.7459 12.1762 10.2172C11.9549 9.68855 11.7336 9.76232 11.5738 9.75002C11.4139 9.73773 11.2418 9.73772 11.0574 9.73772C10.873 9.73772 10.5902 9.7992 10.3443 10.0697C10.0984 10.3402 9.39754 10.9918 9.39754 12.3074C9.39754 13.6353 10.3566 14.9017 10.4918 15.0861C10.627 15.2705 12.3852 17.9754 15.0779 19.1435C15.7172 19.4262 16.2213 19.5861 16.6148 19.709C17.2541 19.9181 17.8443 19.8812 18.3115 19.8197C18.8279 19.7459 19.8975 19.1681 20.1311 18.541C20.3525 17.914 20.3525 17.373 20.291 17.2623C20.2049 17.1394 20.0205 17.0656 19.75 16.9426Z\"                       fill=\"white\"\/>                 <defs>                     <lineargradient id=\"paint0_linear\" x1=\"15.0001\" y1=\"-0.0101066\" x2=\"15.0001\" y2=\"29.9855\"                                     gradientunits=\"userSpaceOnUse\">                         <stop stop-color=\"#61FD7D\"\/>                         <stop offset=\"1\" stop-color=\"#2BB826\"\/>                     <\/lineargradient>                 <\/defs>             <\/svg>         <\/a>     <\/li>     <li class=\"share_item share_item-common\">         <a href=\"#\" class=\"share_link share-copy-link\" id=\"share-copy-link\" rel=\"noopener noreferrer\">             <svg width=\"30\" height=\"30\" viewbox=\"0 0 30 30\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">                 <rect width=\"30\" height=\"30\" rx=\"2\" fill=\"#00D4DD\"\/>                 <path d=\"M15.8313 13.6488C14.5411 12.3741 12.4442 12.3813 11.145 13.665L7.55841 17.2089C6.25927 18.4926 6.25204 20.5645 7.54226 21.8392C8.83248 23.114 10.9294 23.1067 12.2285 21.8231L15.0358 19.0158\"                       stroke=\"white\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>                 <path d=\"M13.993 15.3983C15.2832 16.6731 17.3802 16.6658 18.6793 15.3821L22.2659 11.8382C23.5651 10.5545 23.5723 8.48268 22.2821 7.20792C20.9918 5.93316 18.8949 5.94039 17.5958 7.22408L14.7688 10.0511\"                       stroke=\"white\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>             <\/svg>         <\/a>     <\/li> <\/ul>  <script>\n    document.addEventListener(\"DOMContentLoaded\", function(event) {\n        var tempInput = jQuery('<input type=\"text\">');\n        var curUrl = jQuery(location).attr('href');\n        var shareButton = jQuery('.share-copy-link');\n        shareButton.on('click', function (e) {\n            e.preventDefault();\n            if (navigator.share) {\n                navigator.share({\n                    title: 'Dentaly.org | Your Oral Healthcare Portal',\n                    url: curUrl\n                }).then(() => {\n                    console.log('Thanks for sharing!');\n                }).catch(console.error);\n            } else {\n                jQuery('body').append(tempInput);\n                tempInput.val(curUrl).select();\n                document.execCommand('copy');\n                tempInput.remove();\n                jQuery(this).attr('data-state', 'Link is copied').addClass('copied');\n                setTimeout(function () {\n                    jQuery('.share-copy-link').removeClass('copied');\n                }, 8000);\n            }\n        });\n    });\n<\/script>  <\/div><!--copyscapeskip--><div class=\"medical-references\"><div class=\"medical-references__heading\"><span>Sources<\/span><\/div><div class=\"medical-references__list\"><p><strong>NIH:\u00a0<\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC17626\/\" target=\"_blank\" rel=\"noopener\">Postnatal Human Dental Pulp Stem Cells (DPSCs) in vitro and in vivo<\/a>. Consulted 20th October 2022.<\/p> <p><strong>Mayo.edu: <\/strong><a href=\"https:\/\/www.mayo.edu\/research\/labs\/bone-injury-repair\/research\/mesenchymal-stem-cell-biology#:~:text=Mesenchymal%20stem%20cells%20(MSCs)%20are%20multipotent%20stem%20cells%20found%20in,into%20lipid%2Daccumulating%20fat%20cells.\" target=\"_blank\" rel=\"noopener\">Mesenchymal Stem Cell Biology<\/a>. Consulted 20th October 2022.<\/p> <\/div><\/div><!--\/copyscapeskip-->","protected":false},"excerpt":{"rendered":"<p>Let&#8217;s talk about dental stem cells. A few years ago &#8216;stem cells&#8217; was a buzzword, a hot-button topic that would send politically opposed radicals at each other&#8217;s throats. But today, stem cell research is a rapidly progressing scientific field, with promising medical advances that are greatly improving lives globally. Dental stem cells are currently still &#8230; <a title=\"Dental Stem Cells: Regenerative Dentistry and its Applications\" class=\"read-more\" href=\"https:\/\/www.dentaly.org\/us\/dental-services\/stem-cells\/\">Read more <span class=\"screen-reader-text\">Dental Stem Cells: Regenerative Dentistry and its Applications<\/span><\/a><\/p>\n","protected":false},"author":70,"featured_media":64682,"parent":19461,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":""},"categories":[6946],"tags":[],"coauthors":[2159],"class_list":["post-64612","page","type-page","status-publish","has-post-thumbnail","category-services-category"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dental Stem Cells: Current Research and Practical Applications - Dentaly.org<\/title>\n<meta name=\"description\" content=\"We interview Stemodontics board member, Dr. Ophir Klein, about the latest in dental stem cell research and learn about its future applications.\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dental Stem Cells: Current Research and Practical Applications - Dentaly.org\" \/>\n<meta property=\"og:description\" content=\"We interview Stemodontics board member, Dr. Ophir Klein, about the latest in dental stem cell research and learn about its future applications.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.dentaly.org\/us\/dental-services\/stem-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Dentaly.org\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/dentaly.org\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-12T10:29:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2022\/10\/dental-stem-cells-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"790\" \/>\n\t<meta property=\"og:image:height\" content=\"416\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@dentaly_site\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"8 minutes\" \/>\n\t<meta name=\"twitter:label2\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data2\" content=\"Natalie Asmussen\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/dental-services\\\/stem-cells\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/wp-content\\\/uploads\\\/sites\\\/16\\\/2022\\\/10\\\/dental-stem-cells-2.jpg\",\"contentUrl\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/wp-content\\\/uploads\\\/sites\\\/16\\\/2022\\\/10\\\/dental-stem-cells-2.jpg\",\"width\":790,\"height\":416,\"caption\":\"dental stem cells\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/dental-services\\\/stem-cells\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Dental Services\",\"item\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/dental-services\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Dental Stem Cells\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/#website\",\"url\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/\",\"name\":\"Dentaly.org\",\"description\":\"Your Oral Healthcare Portal\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/#organization\",\"name\":\"Dentaly.org\",\"url\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/wp-content\\\/uploads\\\/sites\\\/16\\\/2024\\\/09\\\/dentaly-logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/wp-content\\\/uploads\\\/sites\\\/16\\\/2024\\\/09\\\/dentaly-logo.svg\",\"width\":561,\"height\":144,\"caption\":\"Dentaly.org\"},\"image\":{\"@id\":\"https:\\\/\\\/www.dentaly.org\\\/us\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/dentaly.org\\\/\",\"https:\\\/\\\/x.com\\\/dentaly_site\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/dentaly-org\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Dental Stem Cells: Current Research and Practical Applications - Dentaly.org","description":"We interview Stemodontics board member, Dr. Ophir Klein, about the latest in dental stem cell research and learn about its future applications.","og_locale":"en_US","og_type":"article","og_title":"Dental Stem Cells: Current Research and Practical Applications - Dentaly.org","og_description":"We interview Stemodontics board member, Dr. Ophir Klein, about the latest in dental stem cell research and learn about its future applications.","og_url":"https:\/\/www.dentaly.org\/us\/dental-services\/stem-cells\/","og_site_name":"Dentaly.org","article_publisher":"https:\/\/www.facebook.com\/dentaly.org\/","article_modified_time":"2024-11-12T10:29:10+00:00","og_image":[{"width":790,"height":416,"url":"https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2022\/10\/dental-stem-cells-2.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_site":"@dentaly_site","twitter_misc":{"Est. reading time":"8 minutes","Written by":"Natalie Asmussen"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.dentaly.org\/us\/dental-services\/stem-cells\/#primaryimage","url":"https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2022\/10\/dental-stem-cells-2.jpg","contentUrl":"https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2022\/10\/dental-stem-cells-2.jpg","width":790,"height":416,"caption":"dental stem cells"},{"@type":"BreadcrumbList","@id":"https:\/\/www.dentaly.org\/us\/dental-services\/stem-cells\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.dentaly.org\/us\/"},{"@type":"ListItem","position":2,"name":"Dental Services","item":"https:\/\/www.dentaly.org\/us\/dental-services\/"},{"@type":"ListItem","position":3,"name":"Dental Stem Cells"}]},{"@type":"WebSite","@id":"https:\/\/www.dentaly.org\/us\/#website","url":"https:\/\/www.dentaly.org\/us\/","name":"Dentaly.org","description":"Your Oral Healthcare Portal","publisher":{"@id":"https:\/\/www.dentaly.org\/us\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.dentaly.org\/us\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.dentaly.org\/us\/#organization","name":"Dentaly.org","url":"https:\/\/www.dentaly.org\/us\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.dentaly.org\/us\/#\/schema\/logo\/image\/","url":"https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2024\/09\/dentaly-logo.svg","contentUrl":"https:\/\/www.dentaly.org\/us\/wp-content\/uploads\/sites\/16\/2024\/09\/dentaly-logo.svg","width":561,"height":144,"caption":"Dentaly.org"},"image":{"@id":"https:\/\/www.dentaly.org\/us\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/dentaly.org\/","https:\/\/x.com\/dentaly_site","https:\/\/www.linkedin.com\/company\/dentaly-org\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/pages\/64612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/users\/70"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/comments?post=64612"}],"version-history":[{"count":28,"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/pages\/64612\/revisions"}],"predecessor-version":[{"id":79132,"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/pages\/64612\/revisions\/79132"}],"up":[{"embeddable":true,"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/pages\/19461"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/media\/64682"}],"wp:attachment":[{"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/media?parent=64612"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/categories?post=64612"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/tags?post=64612"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.dentaly.org\/us\/wp-json\/wp\/v2\/coauthors?post=64612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}