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High Fluoride Toothpaste for Whitening and Cavity Protection

Contributors:  Amanda Dexter

Fluoride is a mineral found in water across the US and is both naturally occurring and added to water to benefit dental health. But is high fluoride toothpaste safe?

This article will discuss the benefits and risks of toothpaste with high fluoride and answer the following questions:

  • What does this type of toothpaste do?
  • Why might you be prescribed a toothpaste with high fluoride? 
  • What is the best high fluoride toothpaste in the US?
  • Are there any high fluoride toothpaste side effects?

We hope this article will help you better understand the advantages and disadvantages of prescription toothpaste and how they might benefit you.

What is high fluoride toothpaste?

Toothpaste can come containing all different levels of fluoride, and some are completely fluoride-free. The regular amount is between 1,000 and 1,500 ppm. These are usually in the form of sodium fluoride or sodium monofluorophosphate.

Fluoride is measured in PPM, which stands for parts per million. This is because the amount you need for it to work effectively is very small. Most adult toothpaste contains between 1,000 and 1,500 and toothpaste for babies and children has on average 1,000 ppm of fluoride.

toothpaste with fluoride
What is the best toothpaste with fluoride in the US?

Many people are worried about giving their kids fluoride, but according to the ADA, children should use toothpaste with fluoride. The ADA also recommends that adults use toothpaste with between 1,000 to 1,500 ppm fluoride. However, your dentist can prescribe a toothpaste with a higher amount of fluoride that contains up to 5,000 ppm of fluoride.

A prescription for toothpaste with high amounts of fluoride may be suitable for some, but remember that it isn’t a replacement for a good dental hygiene routine and regular dental check-ups. 

What does high fluoride toothpaste do?

Toothpaste with high fluoride helps to defend your teeth against tooth decay and dental caries. It does this by remineralizing your teeth and strengthening your enamel. It also helps to defend your teeth against acids from food and drinks. 

While high fluoride can’t rid your teeth of tooth decay or reverse cavities, it can help to strengthen your enamel against decay and protect against cavities. 

Fluoride works to remineralize your teeth by stimulating the production of fluorapatite. This is a type of enamel particularly resistant to acid and bacteria. It also has antibacterial properties that help slow down the growth of bacteria and its ability to stick to your teeth. 

Maintaining a good oral hygiene routine by regularly brushing and flossing your teeth will go a long way in protecting your teeth from tooth decay and cavities. However, if you need a little extra help for any reason your dentist may prescribe extra fluoride toothpaste.

Who needs toothpaste with high levels of fluoride? 

A dentist has to prescribe high fluoride toothpaste containing 5,000 ppm of fluoride. This is because overuse of fluoride can cause dental fluorosis in developing teeth. To get a prescription for this type of toothpaste, your dentist needs to do a dental check-up and assess whether you can benefit from it. 

The main reason your dentist may prescribe toothpaste is if you are at high risk of tooth decay. Generally, those at a higher risk of tooth decay include the following people: 

fluoride containing toothpaste
Those most at risk with tooth decay may be prescribed toothpaste with high fluoride
  • People who regularly skip dental check-ups
  • The elderly 
  • Those with a history of dental decay or currently struggling with dental decay
  • People that eat a lot of high-sugar foods and drinks 
  • Sufferers of dry mouth
  • People with diabetes 
  • Those with poor oral hygiene 
  • Patients undergoing orthodontic treatment
  • Those with receding gums or in need of restorative treatment 
  • People that are on medications containing sugar 

There are a few other reasons that you may need toothpaste with high fluoride if you don’t think you fit into one of these categories. These reasons include: 

  • Tooth sensitivity 
  • Toothache
  • If you have any dark spots on your teeth 
  • A strange taste in your mouth that isn’t going away

If you think you need extra fluoride toothpaste for any of these reasons, book an appointment with your dentist. They will assess your teeth to determine if you would be a good candidate for prescription-only fluoride-containing toothpaste

High fluoride toothpaste side effects

There have been many studies conducted on the safety of fluoride use in toothpaste. The general consensus seems to be that they are safe when used following the manufacturer's guidelines. 

Due to high fluoride toothpaste side effects, it’s important not to swallow any. It should also not be used by children under the age of six. Children under the age of six are more likely to accidentally swallow toothpaste, which can cause dental fluorosis over time. 

Dental fluorosis is when changes occur in the tooth enamel due to hypomineralization. One of the major symptoms is when white spots develop on the teeth. The following table summarizes the recommended amount of toothpaste to use and what fluoride quantities for different ages:


Fluoride concentration

Amount to use

Children under 3

At least 1,000 ppm

A smear

Children 3 - 6

At least 1,000 ppm

A pea-sized amount

Children over 6 and adults

1,350 ppm - 1,500 ppm

A pea-sized amount

What are the commonly prescribed high fluoride kinds of toothpaste available?

Prescription extra-fluoride toothpaste can contain up to 5,000 ppm. However, there are different prescription toothpastes, each with different levels of fluoride from 1,500 ppm to 5,000 ppm. 

They also include different ingredients to suit different dental needs, so your dentist will prescribe the one that best fits your individual circumstances. 

Some of the most common types of toothpaste with the most fluoride that your dentist may prescribe include: 

  • Denta 5000
  • Colgate Prevident 5000
  • Clinpro 5000
  • SF 5000 plus

Colgate Prevident 5000 is one of the highest fluoridated toothpaste available, and you can only get it with a prescription from a dentist. It contains up to 4 times the amount of fluoride as other regular toothpaste and mouthwashes on the market. 

Colgate claims it is best for those that have a high chance of dental cavities, or for those with dental restorations such as crowns or bridges. 

Can you buy high fluoride toothpaste over-the-counter in the US? 

To buy toothpaste with a fluoride content of over 1,500 ppm in the US, you need a prescription. Most over-the-counter adult toothpaste has on average 1,450 ppm of fluoride. 

However, there are kinds of toothpaste available that are specifically designed to help remineralize your teeth, protect against cavities or help with tooth sensitivity. 

Most big toothpaste brands have a selection of fluoride toothpaste specifically designed for tooth decay prevention and tooth remineralization. They all have about 1,450 ppm of fluoride but include different ingredients as well to help protect teeth and strengthen enamel. 

In the following video, Dr. Tyler discusses how to find the best toothpaste for preventing tooth decay and cavities that you can buy over-the-counter in the US:

Let's look past the marketing to find the real differences (and similarities) between toothpastes. A dentist's guide for how to find out what ingredients are in toothpastes and which ones you should be looking out for. What are the differences between the different kinds of fluoride? What is potassium nitrate and why might you want it in your toothpaste? Does whitening toothpaste actually do anything? contact me at askdrtyle[at]

Sensodyne Pronamel Enamel Repair toothpaste

toothpaste for enamel care
Sensodyne Enamel Repair

Sensodyne's Pronamel Enamel Repair is for daily use to help strengthen your enamel and protect against acid erosion from food and drinks. 

Sensodyne claims that its unique formulation helps to lock in minerals and harden your “acid-softened” tooth enamel, which protects against tooth decay and the formation of cavities. 

The active ingredients in this toothpaste are sodium fluoride (0.25%) and potassium nitrate (5%). Potassium nitrate is a key ingredient that helps with tooth sensitivity. 

toothpaste side effects
Colgate Sensitive Enamel Repair

Colgate Sensitive Enamel Repair toothpaste

Colgate's Sensitive Enamel Repair has been clinically proven to reduce teeth sensitivity and helps to repair and protect from enamel damage. 

Its dual-action formula remineralizes enamel and the main active ingredients are potassium nitrate (5%) and sodium fluoride (0.24%).

Regenerate Enamel Science Advanced Toothpaste

remineralizing toothpaste
Regenerate Enamel Science Advanced

Although Regenerate is a lesser-known brand, its fluoride toothpaste formula specifically targets and reverses early enamel erosion. Its NR-5 ingredients combine to help remineralize teeth and strengthen your enamel, leaving them stronger and protecting against tooth decay. 

Its main ingredients are sodium fluoride 0.315% w/w (1,450 ppm fluoride) and potassium nitrate 5% w/w.

Crest Gum & Enamel Repair toothpaste

toothpaste with high fluoride
Crest Gum and Enamel Repair

Crest’s Gum and Enamel Repair is for, as the name suggests, protecting the gums and remineralizing tooth enamel. The active ingredient in this toothpaste is stannous fluoride (10.454%) and hydrated silica for better cleaning action.

This toothpaste provides antibacterial action on the gums, protects teeth from acid erosion and helps to treat sensitive teeth. 

The following table summarizes the products discussed in this article that you can buy from any store without a prescription:




Sensodyne Pronamel Enamel Repair

  • Enamel remineralization

  • Reduced sensitivity

  • Main ingredients: sodium fluoride and potassium nitrate

Colgate Sensitive Enamel Repair

  • Enamel remineralization

  • Reduced teeth sensitivity

  • Main ingredients: potassium nitrate and sodium fluoride

Regenerate Enamel Science

  • Enamel remineralization

  • Reduced teeth sensitivity

  • NR-5 ingredients

  • Main ingredients: sodium fluoride and potassium nitrate

Crest Gum & Enamel Repair

  • Enamel remineralization

  • Hydrated silica for cleaning and whitening

  • Main ingredient: stannous fluoride


High-fluoride toothpaste is any toothpaste that contains over 1,500 ppm of fluoride. To get this type of toothpaste, you need a prescription from your dentist. This is because toothpaste with high fluoride is not suitable for everyone, so you need a dental assessment first. 

Your dentist will only prescribe a toothpaste with high amounts of fluoride if they believe you are particularly at risk or struggle with tooth decay. 

This type of toothpaste is not a replacement for a good oral hygiene routine. However, some people may still struggle with tooth decay, even with a good oral hygiene routine. Some of these people include the elderly, those with diabetes, and people undergoing orthodontic treatment or in need of restorative treatment. 

You cannot buy high-fluoride toothpaste over-the-counter. However, there are kinds of toothpaste available to help tackle tooth sensitivity, enamel erosion, and tooth decay. 

Most big brands of toothpaste have a range to choose from and you should find one for your needs. There are also lesser-known brands that specialize in enamel remineralization and protection against tooth decay such as Regenerate. 


​​Does high fluoride toothpaste whiten teeth?

Fluoride is good for helping strengthen and remineralize tooth enamel. However, excess fluoride can turn your teeth yellow or brown or create white spots. This is called dental fluorosis. 

Fluorosis is unlikely to be caused by fluoride toothpaste. If you choose a whitening toothpaste that contains fluoride it may help whiten teeth, but that will be because of the whitening ingredients and not the fact that it contains fluoride.

What is the toothpaste with the most fluoride?

The toothpaste with the most fluoride will have 5,000 ppm or 1.1% fluoride, and will most likely require a prescription from your dentist. One of the most common examples is Colgate PreviDent 5000.

Is high fluoride toothpaste safe?

If your dentist prescribes you this type of toothpaste and you use it according to their directions, then it is safe. You should make sure not to swallow any of this toothpaste. If not used according to directions you could get tooth discoloration, gum irritation, or allergic reactions.

Why is high fluoride toothpaste prescription only?

You need a prescription for this type of toothpaste because it can cause side effects. If your dentist has prescribed you this toothpaste, it's because they believe the benefits outweigh the risks.

High Fluoride Toothpaste for Whitening and Cavity Protection
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Amanda combines her medical background with her love for writing to bring you informed and accurate content at
Sources High Fluoride Toothpaste. Consulted 22nd April 2022.

ADA: American Dental Association Council on Scientific Affairs. Consulted 22nd April 2022.